The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its SLCterminus. [provided by RefSeq, Mar 2012]
Function:
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
Post-translational modifications:
Autophosphorylated.
Similarity:
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family.
MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 RING-type zinc finger.
Contains 1 SWIM-type zinc finger.
SWISS:
Q13233
Gene ID:
600982
Database links:
Entrez Gene: 4214 Human
Entrez Gene: 21281 Mouse
Entrez Gene: 116667 Rat
Omim: 600982 Human
SwissProt: Q13233 Human
SwissProt: P53349 Mouse
SwissProt: Q62925 Rat
Unigene: 653654 Human
Unigene: 15918 Mouse
Unigene: 11081 Rat
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