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Rabbit Anti-MESDC2 antibody
MESDC2 is a 234 amino acid endoplasmic reticulum protein belonging to the MESD family. Considered a chaperone protein, MESDC2 specifically assists in folding beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) through N- and SLCterminal unstructured regions. MESDC2 modulates the Wnt pathway by chaperoning coreceptors LRP5 and LRP6 to the plasma membrane, and is essential for mesoderm induction and embryonic polarity. The gene encoding MESDC2 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
Function:
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
Subunit:
Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane.
Subcellular Location:
Endoplasmic reticulum.
Similarity:
Belongs to the MESD family.
SWISS:
Q14696
Gene ID:
23184
Database links:
Entrez Gene: 23184 Human
Omim: 607783 Human
SwissProt: Q14696 Human
Unigene: 578450 Human
Unigene: 73476 Human
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