METT10D is a 562 amino acid protein that belongs to the METTL16/rlmF family and methyltransferase superfamily. A putative methyltransferase, METT10D exists as two alternatively spliced isoforms and undergoes phosphorylation in response to DNA damage, most likely by Atm or ATR. The gene encoding METT10D maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is linked to predisposition of cancers of the ovary, colon, prostate gland and fallopian tubes.
Function:
Probable methyltransferase.
Similarity:
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
SWISS:
Q86W50
Gene ID:
79066
Database links:
Entrez Gene: 468142 Chimpanzee
Entrez Gene: 100765063 Chinese Hamster
Entrez Gene: 96655 Dog
Entrez Gene: 100734997 Guinea pig
Entrez Gene: 79066 Human
Entrez Gene: 67493 Mouse
Entrez Gene: 72568 Rat
SwissProt: Q86W50 Human
SwissProt: Q9CQG2 Mouse
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