The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Function:
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
Subcellular Location:
Cytoplasm. Nucleus.
Similarity:
Belongs to the AAA ATPase family.
SWISS:
P43686
Gene ID:
5704
Database links:
Entrez Gene: 5704 Human
Entrez Gene: 737578 Chimpanzee
Entrez Gene: 510029 Cow
Entrez Gene: 23996 Mouse
Entrez Gene: 100341658 Rabbit
Entrez Gene: 117262 Rat
Entrez Gene: 398853 Xenopus laevis
Entrez Gene: 493372 Xenopus tropicalis
Entrez Gene: 326884 Zebrafish
Omim: 602707 Human
SwissProt: Q3T030 Cow
SwissProt: P43686 Human
SwissProt: P54775 Mouse
SwissProt: Q63570 Rat
Unigene: 211594 Human
Unigene: 29582 Mouse
Unigene: 11341 Rat
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