The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Function:
Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
Subcellular Location:
Membrane.
Similarity:
Belongs to the protein-tyrosine phosphatase family.
Receptor class 2B subfamily.
Contains 4 fibronectin type-III domains.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 MAM domain.
Contains 2 tyrosine-protein phosphatase domains.
SWISS:
P28827
Gene ID:
5797
Database links:
Entrez Gene: 5797 Human
Entrez Gene: 57292 Cow
Entrez Gene: 96203 Dog
Entrez Gene: 19274 Mouse
Entrez Gene: 100173948 Orangutan
Entrez Gene: 29616 Rat
Omim: 176888 Human
SwissProt: P28827 Human
SwissProt: P28828 Mouse
Unigene: 49774 Human
Unigene: 32369 Mouse
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