Rrp4 and Ski7p are components of the cytoplasmic exosome complex, and together with the RNA helicase Ski2p they are necessary for degradation of deadenylated mRNA. Rrp4 is required for the 3’ to 5’ exonuclease activity that produces the 3’ end of the 5.8S rRNA. Rrp4 also functions as a subunit of the specialized trypanosome exosome complex.
Function:
The exosome, present in both the nucleus and cytoplasm of all eukaryotic cells, is a complex of 3'-5' exoribonucleases containing at least nine core components. Recently, it has been demonstrated, mainly by analyses in yeast, that the nuclear exosome is essential for rRNA processing and sn(o)RNA biogenesis. Furthermore, it is involved in the degradation of improperly processed mRNAs. The cytoplasmic exosome participates in normal mRNA turnover and in the degradation of inherently instable mRNAs that contain AU-rich elements. Therefore, the exosome plays a key role in RNA metabolism.
Subcellular Location:
Cytoplasmic, Exosome and Nuclear
Similarity:
Belongs to the RRP1 family.
SWISS:
Q13868
Gene ID:
23404
Database links:
Entrez Gene: 615712 Cow
Entrez Gene: 608606 Dog
Entrez Gene: 101126796 Gorilla
Entrez Gene: 23404 Human
Entrez Gene: 100397822 Marmoset (common)
Entrez Gene: 227715 Mouse
Entrez Gene: 100439017 Orangutan
Entrez Gene: 595050 Xenopus tropicalis
GenBank: NP_055100.2 Human
Omim: 602238 Human
SwissProt: Q2KID0 Cow
SwissProt: Q13868 Human
SwissProt: Q8VBV3 Mouse
Unigene: 654643 Huma
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