Rabbit Anti-RSC1A1 antibody

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Regulator Of Solute Carriers 1; Regulatory Solute Carrier Protein, Family 1, Member 1; Transporter Regulator RS1; Regulatory Solute Carrier Protein Family 1 Member 1; HRS1; RS1; RSCA1_HUMAN;

Cat:

SL18866R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human RSC1A1:101-200/617

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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RSC1A1 is 617 amino acid nuclear protein that localizes to the inner side of the plasma membrane and the Golgi apparatus. Expressed in small intestine, kidney and brain, RSC1A1 mediates transcriptional and post-transcriptional regulation of Na(+)-D-glucose cotransporter SGLT-1 (sodium/glucose cotransporter 1). RSC1A1 is thought to inhibit the dynamin-dependent release of SGLT-1-containing vesicles from the TGN (trans-Golgi network). Mutations in the gene encoding RSC1A1 may lead to leptin-independent up-regulation of food intake, which is suggested to be partially responsible for obesity. The gene encoding is RSC1A1 located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.

Function:
Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKSLCdependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity). Regulates the expression of SLC5A1 in a tissue-specific manner and is specifically involved in its regulation in the small intestine.

Subunit:
Interacts with YRDC.

Subcellular Location:
Cell Membrane, Golgi Apparatus and Nuclear.

Tissue Specificity:
Expressed in epithelial and subepithelial cells of small intestine.

SWISS:
Q92681

Gene ID:
6248

Database links:

Entrez Gene: 6248 Human

Entrez Gene: 69994 Mouse

Omim: 601966 Human

SwissProt: Q92681 Human

SwissProt: Q9ER99 Mouse

Unigene: 657818 Human

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