This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]
Function:
Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain.
Subunit:
Interacts with SMARCA5/SNF2H to form the RSF complex. Also binds the HBV pX/HBx protein, which is required to activate transcription of the viral genome.
Subcellular Location:
Nucleus
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Contains 1 DDT domain.
Contains 1 PHD-type zinc finger.
SWISS:
Q96T23
Gene ID:
51773
Database links:
Entrez Gene: 51773 Human
Entrez Gene: 476797 Dog
Entrez Gene: 233532 Mouse
Omim: 608522 Human
SwissProt: Q96T23 Human
Unigene: 420229 Human
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