R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 13366) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]
Function:
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.
Subunit:
Interacts with WNT1. Binds heparin By similarity. Interacts with LGR4, LGR5 and LGR6.
Subcellular Location:
Secreted
Similarity:
Belongs to the R-spondin family.
Contains 1 FU (furin-like) repeat.
Contains 1 TSP type-1 domain.
SWISS:
Q6UXX9
Gene ID:
340419
Database links:
Entrez Gene: 340419 Human
Entrez Gene: 239405 Mouse
Entrez Gene: 500863 Rat
Omim: 610575 Human
SwissProt: Q6UXX9 Human
SwissProt: Q8SFU0 Mouse
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