This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
Function:
Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.
Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side
Tissue Specificity:
Highly expressed in heart and brain.
Similarity:
Contains 7 LRR (leucine-rich) repeats.
SWISS:
Q15404
Gene ID:
6251
Database links:
Entrez Gene: 6251 Human
Entrez Gene: 617534 Cow
Entrez Gene: 20163 Mouse
Entrez Gene: 136419 Rat
Entrez Gene: 553276 Zebrafish
Omim: 179555 Human
SwissProt: Q5E9C0 Cow
SwissProt: Q15404 Human
SwissProt: Q01730 Mouse
Unigene: 524161 Human
Unigene: 905 Mouse
Unigene: 11453 Rat
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