Rabbit Anti-PDE10A antibody

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5''-cyclic phosphodiesterase 10A; cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A; cAMP and cAMP-inhibited cGMP 3''; cAMP and cAMP-inhibited cGMP 3'5'-cyclic phosphodiesterase 10A; FLJ11894; HSPDE 10A; HSPDE10A; PDE 10A; PDE10_HUMAN

Cat:

SL18883R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human PDE10A:241-340/779

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.

Subcellular Location:
Cytoplasm. Located mostly to soluble cellular fractions.

Tissue Specificity:
Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.

Similarity:
Belongs to the cyclic nucleotide phosphodiesterase family. Contains 2 GAF domains.

SWISS:
Q9Y233

Gene ID:
10846

Database links:

Entrez Gene: 10846 Human

Entrez Gene: 23984 Mouse

Entrez Gene: 63885 Rat

Omim: 610652 Human

SwissProt: Q9Y233 Human

SwissProt: Q8CA95 Mouse

SwissProt: Q9QYJ6 Rat

Unigene: 348762 Human

Unigene: 87161 Mouse

Unigene: 44869 Rat

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