This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Function:
Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.
Subunit:
Interacts via its SLCterminal region with the TAX1BP3 PDZ domain. This interaction facilitates Rho-mediated activation of the c-Fos serum response element (SRE). Interacts with SEPT9. Specifically binds to GTP-bound RHOA, RHOB and RHOC and inhibits their GTPase activity.
Tissue Specificity:
Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested. Overexpressed in various cancer cell lines.
Similarity:
Contains 1 PH domain.
Contains 1 REM (Hr1) repeat.
SWISS:
Q9BST9
Gene ID:
6242
Database links:
Entrez Gene: 6242 Human
Entrez Gene: 20166 Mouse
Entrez Gene: 297383 Rat
Omim: 602288 Human
SwissProt: Q9BST9 Human
SwissProt: Q8C6B2 Mouse
SwissProt: Q6V7V2 Rat
Unigene: 192854 Human
Unigene: 4139 Mouse
Unigene: 224634 Rat
Unigene: 233799 Rat
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