NgR2 belongs to the Nogo receptor family and contains eight LRR (leucine-rich) repeats, one LRRNT domain and a single LRRCT domain. The gene encoding NgR2 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
Function:
May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
Subcellular Location:
Cell membrane
Tissue Specificity:
Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.
Post-translational modifications:
Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.
Similarity:
Belongs to the Nogo receptor family.
Contains 8 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
SWISS:
Q86UN3
Gene ID:
349667
Database links:
Entrez Gene: 349667 Human
Entrez Gene: 269295 Mouse
Entrez Gene: 311169 Rat
Omim: 610462 Human
SwissProt: Q86UN3 Human
SwissProt: Q7M6Z0 Mouse
SwissProt: Q80WD1 Rat
Unigene: 502618 Human
Unigene: 389289 Mouse
Unigene: 86447 Mouse
Unigene: 162683 Rat
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