RTP2 is a 225 amino acid single-pass type III membrane protein whose cell surface expression is dependent on olfactory receptor interaction. RTP2 belongs to the TMEM7 family, playing a role in both the function of odorant receptors and their translocation to the plasma membrane. RTP2 is highly expressed olfactory and vomeronasal organs with low expression in brain. While RTP2 lacks a signal peptide it contains a SLCterminal transmembrane domain. The gene encoding RTP2 maps to human chromosome 3q27.3.
Function:
Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs
Subunit:
Interacts with olfactory receptors
Subcellular Location:
Cell membrane
Similarity:
Belongs to the TMEM7 family.
SWISS:
Q5QGT7
Gene ID:
344892
Database links:
Entrez Gene: 344892 Human
Entrez Gene: 24855 Mouse
Omim: 609138 Human
SwissProt: Q5QGT7 Human
SwissProt: Q80ZI2 Mouse
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