This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Function:
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.
Subcellular Location:
Cytoplasm. Early endosome membrane.
Tissue Specificity:
Broadly expressed, with highest levels in lung, testis, kidney and brain.
Post-translational modifications:
Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 1 FYVE-type zinc finger.
Contains 1 RUN domain.
SWISS:
Q96T51
Gene ID:
80230
Database links:
Entrez Gene: 80230 Human
Entrez Gene: 216724 Mouse
Entrez Gene: 72521 Rat
Omim: 610327 Human
SwissProt: Q96T51 Human
SwissProt: Q8BIJ7 Mouse
Unigene: 306769 Human
Unigene: 390400 Mouse
Unigene: 39348 Rat
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