This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Function:
Also functions as a glutathione peroxidase.
Subcellular Location:
Endoplasmic reticulum membrane. Microsome membrane. Microsome membrane.
Tissue Specificity:
Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.
Similarity:
Belongs to the MAPEG family.
SWISS:
O14176
Gene ID:
4259
Database links:
Entrez Gene: 4259 Human
Entrez Gene: 66447 Mouse
Entrez Gene: 289197 Rat
Omim: 604564 Human
SwissProt: O14176 Human
SwissProt: Q9CPU4 Mouse
Unigene: 191734 Human
Unigene: 218286 Mouse
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