Rabbit Anti-MICAL2 antibody

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flavoprotein oxidoreductase MICAL2; KIAA0750; MICAL2PV1; MICAL2PV2; microtubule associated monoxygenase, calponin and LIM domain containing 2; Molecule interacting with CasL protein 2; Protein-methionine sulfoxide oxidase MICAL2.

Cat:

SL18933R

Species Reactivity：

(predicted: Human,Mouse,Rat,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human MICAL2:601-700/1124

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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MICAL2 is a 1,124 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one LIM zinc-binding domain and one calponin-homology domain. Using FAD as a cofactor, MICAL2 interacts with Rab 1B, plexin-A4 and Vimentin and, via these interactions, may play a role in cytoskeletal regulation, specifically at intermediate filaments. MICAL2, which exists as two alternatively spliced isoforms, is expressed at high levels in heart and brain and at lower levels in ovary, skeletal muscle, liver, testis and kidney tissue.

Function:
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Subunit:
Interacts with VIM and PLXNA4 By similarity. Interacts with RAB1B.

Subcellular Location:
Cytoplasm; Nucleus; cytoskeleton.

Similarity:
Belongs to the Mical family.
Contains 1 CH (calponin-homology) domain.
Contains 1 LIM zinc-binding domain.

SWISS:
O94851

Gene ID:
9645

Database links:

Entrez Gene: 534041 Cow

Entrez Gene: 476858 Dog

Entrez Gene: 9645 Human

Entrez Gene: 64878 Mouse

Entrez Gene: 365352 Rat

Omim: 608881 Human

SwissProt: F1MF74 Cow

SwissProt: O94851 Human

SwissProt: Q8BML1 Mouse

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