The mesoderm induction early response (MIER) protein family (also known as the fibroblast growth factor (FGF)-regulated immediate-early protein family) comprises a group of proteins that are activated by FGF (fibroblast growth factor). This suggests that MEIR proteins may play a significant role in FGF-regulated cellular activities and in the progression of certain cancers. MIER proteins contain one SANT domain, which is involved in transcriptional activation and repression, and one ELM2 domain, which was first characterized in egl-27, a gene that is critically involved in embryonic patterning of C. elegans. MIER1, formerly known as early response 1 (ER1), was first cloned and characterized in Xenopus. Expression of MIER1 is negligible in most normal tissues, but has been found to be upregulated in breast carcinoma cell lines and tumors. MIER1 functions as a transcriptional repressor of a number of genes including Sp1 target genes, most likely through interaction with HDAC1.
Function:
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.
Subunit:
Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
Subcellular Location:
Nucleus; Cytoplasm
Tissue Specificity:
Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.
Similarity:
Contains 1 ELM2 domain.
Contains 1 SANT domain.
SWISS:
Q7Z3K6
Gene ID:
166968
Database links:
Entrez Gene: 166968 Human
SwissProt: Q7Z3K6 Human
SwissProt: Q7Z3K6-1 Human
SwissProt: Q7Z3K6-2 Human
SwissProt: Q7Z3K6-3 Human
SwissProt: Q7Z3K6-4 Human
SwissProt: Q7Z3K6-5 Human
Unigene: 657594 Human
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