MITD1 is a 249 amino acid peripheral membrane protein that localizes to the cytoplasmic side of late endosomes, where it is Implicated in endosomal protein transport. MITD1 interacts with CHMP2 and CHMP1B, and is encoded by a gene that maps to human chromosome 2q11.2. As the second largest human chromosome, chromosome 2 consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome is due to mutations in the ALMS1 gene.
Function:
Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.
Subunit:
Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1.
Subcellular Location:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side.
Similarity:
Contains 1 MIT domain.
SWISS:
Q8WV92
Gene ID:
129531
Database links:
Entrez Gene: 129531 Human
Entrez Gene: 69028 Mouse
Entrez Gene: 363219 Rat
SwissProt: Q8WV92 Human
SwissProt: Q8VDV8 Mouse
SwissProt: Q5I0J5 Rat
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