The gene encoding the Mixed-Lineage Leukemia (MLL) proteins is located on chromosome 11q23. Chromosomal translocations involving band 11q23 result in rogue activator proteins that are associated with approximately 10% of patients with acute lymphoblastic leukemia (ALL) and 5% of patients with acute myeloid leukemia (AML). Most patients affected are less than 1 year of age. The gene encoding MLLT6, also known as mixed-lineage leukemia translocated to 6 or AF17, is located on chromosome 17q12 and encodes a 1093 amino acid protein that is thought to be involved in the translocations on chromosome 11q23. Localized to the nucleus, MLLT6 contains a leucine-zipper dimerization motif located 3-prime of the fusion point and a cysteine-rich domain at the SLCterminus. MLLT6 is thought to play a role in ALL by repressing the activity of the truncated ALL1 protein.
Subcellular Location:
Nucleus.
DISEASE:
Note=A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocation t(11;17)(q23;q21) with MLL/HRX. The result is a rogue activator protein.
Similarity:
Contains 2 PHD-type zinc fingers.
SWISS:
P55198
Gene ID:
4302
Database links:
Entrez Gene: 4302 Human
Entrez Gene: 246198 Mouse
Entrez Gene: 303504 Rat
Omim: 600328 Human
SwissProt: P55198 Human
Unigene: 91531 Human
Unigene: 23685 Mouse
Unigene: 222490 Rat
|
|
