This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a SLCterminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Function:
Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain.
Subunit:
Can form homodimers. Interacts with STARD3NL.
Subcellular Location:
Late endosome membrane.
Similarity:
Contains 1 MENTAL domain.
Contains 1 START domain.
SWISS:
Q14849
Gene ID:
10948
Database links:
Entrez Gene: 10948 Human
Entrez Gene: 59045 Mouse
Entrez Gene: 363675 Rat
Omim: 607048 Human
SwissProt: Q14849 Human
SwissProt: Q61542 Mouse
Unigene: 728838 Human
Unigene: 265546 Mouse
Unigene: 145430 Rat
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