This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]
Function:
May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin.
Subcellular Location:
Secreted
Tissue Specificity:
Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase
Similarity:
Belongs to the peptidase M10A family.
Contains 4 hemopexin repeats.
SWISS:
Q8N119
Gene ID:
118856
Database links:
Entrez Gene: 118856 Human
Entrez Gene: 214766 Mouse
Entrez Gene: 293573 Rat
Omim: 608416 Human
SwissProt: Q8N119 Human
SwissProt: Q8K3F2 Mouse
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