This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]
Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function.
Subcellular Location:
Membrane.
Tissue Specificity:
Found to be expressed in testis and placenta, and at lower levels in all the examined tissues with the exception of liver. Isoform 5 was found in leukocytes but not in brain, retina or testis.
Similarity:
Contains 5 IQ domains.
Contains 2 myosin head-like domains.
Contains 2 phorbol-ester/DAG-type zinc fingers.
Contains 1 Ras-associating domain.
Contains 1 Rho-GAP domain.
SWISS:
B2RTY4
Gene ID:
4649
Database links:
Entrez Gene: 4649 Human
Entrez Gene: 270163 Mouse
Entrez Gene: 171296 Rat
Omim: 604875 Human
SwissProt: B2RTY4 Human
SwissProt: Q8C170 Mouse
SwissProt: Q9Z1N3 Rat
Unigene: 546268 Human
Unigene: 249545 Mouse
Unigene: 88901 Rat
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