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Rabbit Anti-N myc interactor antibody
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
Function:
May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.
Subunit:
Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif. Interacts with all STAT proteins except STAT2.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver.
Similarity:
Belongs to the NMI family.
SWISS:
Q13287
Gene ID:
9111
Database links:
Entrez Gene: 9111 Human
Omim: 603525 Human
SwissProt: Q13287 Human
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