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Rabbit Anti-PPP2R2A antibody
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Subunit:
Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD By similarity. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53.
Tissue Specificity:
Expressed in all tissues examined.
Similarity:
Belongs to the phosphatase 2A regulatory subunit B family.
Contains 7 WD repeats.
SWISS:
P63151
Gene ID:
5520
Database links:
Entrez Gene: 5520 Human
Entrez Gene: 71978 Mouse
Entrez Gene: 117104 Rat
Omim: 604941 Human
SwissProt: P63151 Human
SwissProt: Q6P1F6 Mouse
SwissProt: P63150 Rabbit
SwissProt: P36876 Rat
Unigene: 146339 Human
Unigene: 273997 Mouse
Unigene: 81155 Rat
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