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Rabbit Anti-NAALADL1 antibody
NAALADL1 is a 740 amino acid single-pass type II membrane protein that localizes to the apical cell membrane. Belonging to the peptidase M28 family and the M28B subfamily, NAALADL1 is mainly expressed in the distal small intestine but is also expressed in spleen and tesits. NAALADL1 is considered a novel ileal brush border membrane protein,NAALADL1 is thought to have dipeptidyl-peptidase IV type activity. NAALADL1 exists as eight alternatively spliced isoforms and is encoded by a gene located on human chromosome 11q13.1.
Function:
NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Subcellular Location:
Apical cell membrane; Single-pass type II membrane protein. Note: Ileal brush border membrane.
Tissue Specificity:
Mainly expressed in the distal small intestine. Also expressed in the spleen and testis. Weak expression in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. Isoform 2 and 3 isoform 3 are found in the small intestine and colon.
Similarity:
Belongs to the peptidase M28 family. M28B subfamily.
SWISS:
Q9UQQ1
Gene ID:
10004
Database links:
Entrez Gene: 10004 Human
Omim: 602128 Human
SwissProt: Q9UQQ1 Human
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