Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of Egr1/NGFI-A. Both NAB1 and NAB2 contain an amino-terminal NAB-conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy-terminal NCD2, which is responsible for the repressor function of NAB proteins. NAB1 requires NGFI-A to gain access to DNA, indicating that NAB1 is an active repressor that works by a direct mechanism. NAB1, which is constitutively expressed, is localized exclusively in the nucleus and may play a role in controlling processes such as cell division, differentiation and apoptosis.
Function:
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.
Subcellular Location:
Nucleus.
Tissue Specificity:
Isoform Short is found in a myeloid leukemia cell line.
Similarity:
Belongs to the NAB family.
SWISS:
Q13506
Gene ID:
4664
Database links:
Entrez Gene: 4664 Human
Entrez Gene: 17936 Mouse
Entrez Gene: 64824 Rat
Omim: 600800 Human
SwissProt: Q13506 Human
SwissProt: Q61122 Mouse
SwissProt: Q62722 Rat
Unigene: 723892 Human
Unigene: 25903 Mouse
Unigene: 10099 Rat
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