NACA2, Nascent polypeptide associated complex subunit alpha 2, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) by binding to nascent polypeptide chains as they emerge from the ribosome and blocking their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. NACA2 also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites).
Function:
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites)
Subunit:
Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains
Subcellular Location:
Cytoplasmic and Nuclear
Tissue Specificity:
Expressed specifically in testis and skeletal muscle.
Similarity:
Belongs to the NASLCalpha family.
Contains 1 NASLCA/B (NASLCalpha/beta) domain.
Contains 1 UBA domain.
SWISS:
Q9H009
Gene ID:
342538
Database links:
Entrez Gene: 342538 Human
GenBank: NM_199290.3 Human
Omim: 609274 Human
SwissProt: Q9H009 Human
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