This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008]
Function:
Transcriptional repressor that represses lung-specific expression.
Post-translational modifications:
Nucleus.
Similarity:
Contains 1 C2H2-type zinc finger.
Contains 1 fork-head DNA-binding domain.
SWISS:
Q8IVH2
Gene ID:
116113
Database links:
Entrez Gene: 116113 Human
Entrez Gene: 74123 Mouse
Entrez Gene: 363185 Rat
Omim: 608924 Human
SwissProt: Q5W098 Human
SwissProt: Q8IVH2 Human
SwissProt: Q80V92 Mouse
SwissProt: Q8CG10 Mouse
SwissProt: Q8CIS1 Mouse
SwissProt: Q9DBY0 Mouse
Unigene: 131436 Human
Unigene: 48062 Mouse
Unigene: 64329 Rat
| Picture |
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FOXP4) Polyclonal Antibody, Unconjugated (SL10990R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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