This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]
Function:
Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
Tissue Specificity:
Ubiquitous.
Similarity:
Contains 1 AFP-like domain.
SWISS:
Q9NR45
Gene ID:
54187
Database links:
Entrez Gene: 540602 Cow
Entrez Gene: 54187 Human
Entrez Gene: 94181 Mouse
Entrez Gene: 59671 Rat
Omim: 605202 Human
SwissProt: Q9NR45 Human
Unigene: 522310 Human
Unigene: 665191 Human
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