This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Function:
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the arylamine N-acetyltransferase family.
SWISS:
P1888
Gene ID:
9
Database links:
Entrez Gene: 9 Human
Entrez Gene: 17960 Mouse
Entrez Gene: 116631 Rat
Omim: 108345 Human
SwissProt: P1888 Human
SwissProt: P50294 Mouse
SwissProt: P50297 Rat
Unigene: 2 Human
Unigene: 591847 Human
Unigene: 14125 Mouse
Unigene: 37420 Rat
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