Home
>
Product
>
Antibody
>
Rabbit Anti-NBEAL2 antibody
The protein encoded by this gene contains a beige and Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may play a role in megakaryocyte alpha-granule biogenesis. Mutations in this gene are a cause of gray platelet syndrome. [provided by RefSeq, Dec 2011]
Function:
Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis.
Subcellular Location:
Endoplasmic reticulum.
Tissue Specificity:
Expressed in megakaryocytes.
DISEASE:
Gray platelet syndrome (GPS) [MIM:139090]: A rare platelet disorder characterized by a selective deficiency in the number and contents of platelet alpha-granules. It is associated with mild to moderate bleeding tendency and moderate thrombocytopenia. The platelets are enlarged and have a gray appearance on light microscopy of Wright-stained peripheral blood smears due to decreased granules.
Similarity:
Belongs to the WD repeat neurobeachin family.
Contains 1 BEACH domain.
Contains 5 WD repeats.
SWISS:
Q6ZNJ1
Gene ID:
23218
Database links:
Entrez Gene: 23218 Human
Omim: 614169 Human
SwissProt: Q6ZNJ1 Human
Unigene: 437043 Human
|
|