The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Function:
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
Subcellular Location:
Cytoplasm. Cytoplasmic vesicle; autophagosome. Lysosome. Cytoplasm; myofibril; sarcomere; M line. In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation.
Similarity:
Contains 1 OPR domain.
Contains 1 UBA domain.
Contains 1 ZZ-type zinc finger.
SWISS:
Q14596
Gene ID:
4077
Database links:
Entrez Gene: 4077 Human
Entrez Gene: 17966 Mouse
Entrez Gene: 303554 Rat
Omim: 166945 Human
SwissProt: Q14596 Human
SwissProt: P97432 Mouse
SwissProt: Q501R9 Rat
Unigene: 277721 Human
Unigene: 708158 Human
Unigene: 784 Mouse
Unigene: 94975 Rat
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