NCCRP1 is a 275 amino acid protein that contains one FBA (F-box associated) domain. The gene encoding NCCRP1 maps to human chromosome 19q13.2. Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families, and Fcα receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3.
Function:
Promotes cell proliferation.
Subcellular Location:
Cytoplasm
Tissue Specificity:
Expressed in the esophagus, oral cavity, skin, tongue and reproductive organs.
Similarity:
Contains 1 FBA (F-box associated) domain.
SWISS:
Q6ZVX7
Gene ID:
342897
Database links:
Entrez Gene: 342897 Human
Entrez Gene: 233038 Mouse
SwissProt: Q6ZVX7 Human
Unigene: 726934 Human
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