MCHR, a member of the G protein coupled receptor family 1, is an integral plasma membrane protein which binds melanin concentrating hormone. MCHR can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, MCHR does not seem to bind somatostatin.
Function:
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
Subunit:
Interacts with NCDN.
Subcellular Location:
Cell Membrane; multi-pass membrane protein
Tissue Specificity:
Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
Q99705
Gene ID:
2847
Database links:
Entrez Gene: 2847 Human
Entrez Gene: 207911 Mouse
Entrez Gene: 83567 Rat
Omim: 601751 Human
SwissProt: Q99705 Human
SwissProt: Q8JZL2 Mouse
SwissProt: P97639 Rat
Unigene: 248122 Human
Unigene: 323523 Mouse
Unigene: 10822 Rat
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