NCoA-7 is a 942 amino acid nuclear protein that enhances nuclear receptor transcriptional activities and coactivates several nuclear receptors including PPAR©, ERå, TR∫1 and RARå. Highly expressed in brain and weakly expressed in pancreas, bladder, ovary, spinal cord, prostate, mammary gland, ovary, uterus and stomach, NCoA-7 is a member of the OXR1 family and contains one LysM repeat and a TLD domain. Six NCoA-7 isoforms are known to exist due to alternative splicing events, and the gene encoding NCoA-7 maps to human chromosome 6q22.31 and mouse chromosome 10 A4.
Function:
Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.
Subunit:
Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR-ARNT.
Subcellular Location:
Nucleus
Tissue Specificity:
Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.
Similarity:
Belongs to the OXR1 family.
Contains 1 LysM repeat.
Contains 1 TLD domain.
SWISS:
Q8NI08
Gene ID:
135112
Database links:
Entrez Gene: 135112 Human
Omim: 609752 Human
SwissProt: Q8NI08 Human
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