This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]
Function:
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate.
Subcellular Location:
Golgi apparatus membrane.
Similarity:
Belongs to the sulfotransferase 1 family. NDST subfamily.
SWISS:
P52849
Gene ID:
8509
Database links:
Entrez Gene: 286838 Cow
Entrez Gene: 489049 Dog
Entrez Gene: 100725589 Guinea pig
Entrez Gene: 100064113 Horse
Entrez Gene: 8509 Human
Entrez Gene: 17423 Mouse
Entrez Gene: 100151795 Pig
Entrez Gene: 100357859 Rabbit
Entrez Gene: 114002 Rat
Entrez Gene: 798226 Zebrafish
Omim: 603268 Human
SwissProt: O97583 Cow
SwissProt: P52849 Human
SwissProt: P52850 Mouse
Unigene: 654758 Human
Unigene: 4084 Mouse
Unigene: 7781 Rat
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