This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]
Function:
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.
Subcellular Location:
Golgi apparatus membrane.
Tissue Specificity:
Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle.
Similarity:
Belongs to the sulfotransferase 1 family. NDST subfamily.
SWISS:
O95803
Gene ID:
9348
Database links:
Entrez Gene: 9348 Human
Entrez Gene: 83398 Mouse
Entrez Gene: 295430 Rat
Omim: 603950 Human
SwissProt: O95803 Human
SwissProt: Q9EQH7 Mouse
Unigene: 96596 Human
Unigene: 443908 Mouse
Unigene: 487979 Mouse
Unigene: 228192 Rat
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