The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jan 2011]
Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular Location:
Mitochondrion inner membrane.
Similarity:
Belongs to the complex I NDUFB6 subunit family.
SWISS:
O95139
Gene ID:
4712
Database links:
Entrez Gene: 4712 Human
Entrez Gene: 230075 Mouse
Omim: 603322 Human
SwissProt: O95139 Human
SwissProt: Q3UIU2 Mouse
Unigene: 493668 Human
Unigene: 1103 Mouse
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