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Rabbit Anti-NECAP1 antibody
NECAP 1 is a 275 amino acid cell membrane protein belonging to the NECAP family that localizes to the clathrin-coated vesicle membrane. NECAP 1 is encoded by a gene that maps to human chromosome 12p13.31 and contains two WXXF motifs that are used to mediate binding of accessory proteins to ear domains of various proteins such as AP-1, AP-2 and GGAs. Expressed primarily in brain and existing as two alternatively spliced isoforms, NECAP 1 colocalizes with AP-2 at the plasma membrane by binding AP-2s alpha-ear domain.
Function:
Involved in endocytosis.
Subcellular Location:
Cytoplasmic vesicle > clathrin-coated vesicle membrane. Cell membrane. Colocalizes with AP-2 at the plasma membrane.
Similarity:
Belongs to the NECAP family.
SWISS:
Q8NC96
Gene ID:
25977
Database links:
Entrez Gene: 504449 Cow
Entrez Gene: 67602 Mouse
Entrez Gene: 312694 Rat
SwissProt: Q3T093 Cow
SwissProt: Q9CR95 Mouse
SwissProt: P69682 Rat
Unigene: 52837 Cow
Unigene: 288114 Mouse
Unigene: 58356 Rat
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