Rabbit Anti-Multimerin 2 antibody

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Elastin microfibril interface located protein 3; Elastin microfibril interfacer 3; EMILIN like protein EndoGlyx 1; EMILIN-3; EMILIN3; ENDOGLYX 1; EndoGlyx-1; EndoGlyx-1 p125/p140 subunit; ENDOGLYX1; MMRN2; MMRN2_HUMAN; Multimerin-2.

Cat:

SL19097R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human Multimerin 2:361-460/949

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]

Function:
Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.

Subcellular Location:
Secreted > extracellular space > extracellular matrix.

Tissue Specificity:
Endothelium.

Post-translational modifications:
N- and O-glycosylated.

Similarity:
Contains 1 C1q domain.
Contains 1 EMI domain.

SWISS:
Q9H8L6

Gene ID:
79812

Database links:

Entrez Gene: 79812 Human

Omim: 608925 Human

SwissProt: Q9H8L6 Human

Unigene: 524479 Human

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