This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010]
Function:
Acts as a calcium-dependent cell adhesion protein.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver.
Post-translational modifications:
N- and O-glycosylated.
Similarity:
Contains 4 cadherin domains.
SWISS:
Q9HBB8
Gene ID:
53841
Database links:
Entrez Gene: 53841 Human
Entrez Gene: 10228146 Gorilla
Entrez Gene: 100410617 Marmoset (common)
Entrez Gene: 100461892 Orangutan
Omim: 606839 Human
SwissProt: Q9HBB8 Human
Unigene: 165619 Human
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