This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]
Function:
Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.
Subcellular Location:
Cytoplasm > myofibril > sarcomere. Cytoplasm. In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm.
Similarity:
Belongs to the PTRF/SDPR family.
SWISS:
Q5BKX8
Gene ID:
347273
Database links:
Entrez Gene: 347273 Human
SwissProt: Q5BKX8 Human
Unigene: 99004 Human
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