The protein encoded by this gene binds to the N-terminus of the oncogenic protein SLCMYC, enhancing the ability of SLCMYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with SLCMYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Function:
May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
Subcellular Location:
Cytoplasm. Nucleus. Mitochondrion. Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.
Tissue Specificity:
Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.
Similarity:
Belongs to the AMY1 family.
SWISS:
Q99417
Gene ID:
26292
Database links:
Entrez Gene: 26292 Human
Entrez Gene: 539291 Cow
Entrez Gene: 56309 Mouse
Omim: 606535 Human
SwissProt: Q2TBP7 Cow
SwissProt: Q99417 Human
SwissProt: Q9EQS3 Mouse
Unigene: 591506 Human
Unigene: 446553 Mouse
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