ZFR is 1,074 amino acid RNA-binding protein. In human, ZFR is expressed in lung, liver, lymphocytes, heart, pancreas, kidney and placenta, and regulates postimplantation and gastrulation stages of development. Murine ZFR is observed in testis, ovary and brain. With elevated levels of expression during meiosis, ZFR associates with chromosome foci in meiotic cells. ZFR contains 1 DZF domain and localizes in the somatodendritic compartment of hippocampal neurons and colocalizes with STAU2 in cytosolic RNA granules. Knockout of ZFR in mouse embryo prevents the development of some embryonic structures leads to an increase in programmed cell death with a decrease in mitotic index.
Function:
Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA.
Subcellular Location:
Nucleus. Cytoplasm. Cytoplasmic granule. Chromosome. Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules.
Tissue Specificity:
Expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain and kidney.
Similarity:
Contains 1 DZF domain.
SWISS:
Q96KR1
Gene ID:
51663
Database links:
Entrez Gene: 51663 Human
Entrez Gene: 22763 Mouse
Entrez Gene: 365703 Rat
Entrez Gene: 321659 Zebrafish
SwissProt: Q96KR1 Human
SwissProt: O88532 Mouse
SwissProt: Q562A2 Rat
SwissProt: Q6PCR6 Zebrafish
Unigene: 435231 Human
Unigene: 273496 Mouse
Unigene: 11634 Rat
Unigene: 26724 Zebrafish
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Sample:
Lane 1: Siha (Human) Cell Lysate at 30 ug
Lane 2: HL60 (Human) Cell Lysate at 30 ug
Lane 3: K562 (Human) Cell Lysate at 30 ug
Lane 4: Hela (Human) Cell Lysate at 30 ug
Primary: Anti-ZFR (SL19137R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 117 kD
Observed band size: 117 kD
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