Rabbit Anti-Myelin expression factor 2 antibody

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MYEF2; KIAA1341; MEF 2; MST156; MYEF2_HUMAN; MYEF 2; Myelin expression factor 2.

Cat:

SL19142R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human Myelin expression factor 2:1-100/600

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Myelin basic protein (MBP) binds to negatively charged lipids on the cytosolic surface of oligodendrocyte membranes and is responsible for adhesion of these surfaces in multilayered Myelin sheaths. As a member of a larger family of proteins with many forms and post-translational modifications, MBP appears to have several other functions as a result of these modifications, including participating in the transmission of extracellular signals, as well as cell signaling. These modifications of MBP are dynamic during normal central nervous system (CNS) development and during Myelin degeneration in multiple sclerosis (MS). Regulation of the human MBP gene occurs at the MB1 regulatory motif located between nucleotides -14 to -50. The MB1 element contains binding sites for both the activator protein MEF-1/Pur?and the repressor protein MYEF2. MYEF2 is a nuclear protein whose expression is developmentally regulated in mouse brain with peak expression occurring at postnatal day 7. Four isoforms of MYEF2 exist due to alternative splicing events.

Function:
Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCSLC3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA.

Subunit:
Monomer (By similarity).

Subcellular Location:
Nuclear

Similarity:
Contains 3 RRM (RNA recognition motif) domains.

SWISS:
Q9P2K5

Gene ID:
50804

Database links:

Entrez Gene: 50804 Human

Entrez Gene: 17876 Mouse

SwissProt: Q9P2K5 Human

SwissProt: Q8C854 Mouse

Unigene: 6638 Human

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