Rabbit Anti-phospho-MYL12B (Ser20) antibody

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Mylc2b (phospho S20); p-b (phospho S20);ML12B_HUMAN; MLC-2; MLC-2a; MLC-B; MLC20; MRLC2; MYL12B; MYLC2B; Myosin light chain 12B regulatory; Myosin regulatory light chain 12B; myosin regulatory light chain 2; Myosin regulatory light chain 2-B; myosin regul

Cat:

SL19149R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human Mylc2b around the phosphorylation site of Ser20:AT(p-S)NV

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $256.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]

Function:
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.

Tissue Specificity:
Ubiquitously expressed in various hematopoietic cells.

Post-translational modifications:
Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment.

Similarity:
Contains 3 EF-hand domains.

SWISS:
P24844

Gene ID:
10398

Database links:

Entrez Gene: 10398 Human

Entrez Gene: 98932 Mouse

Entrez Gene: 296313 Rat

Omim: 609905 Human

SwissProt: P20689 Human

SwissProt: P24844 Human

SwissProt: Q9CQ19 Mouse

SwissProt: Q64122 Rat

Unigene: 504687 Human

Unigene: 271770 Mouse

Unigene: 228729 Rat

Unigene: 6870 Rat

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