The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Sep 2011]
The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. Interferon alpha is produced primarily by plasmacytoid dendritic cells and is a potent component of the anti viral innate immune response; it modulates adaptive immunity.
Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular Location:
Secreted.
Similarity:
Belongs to the alpha/beta interferon family.
SWISS:
P01562
Gene ID:
3439
Database links:
Entrez Gene: 3439 Human
Entrez Gene: 3447 Human
Omim: 147660 Human
SwissProt: P01562 Human
Unigene: 37026 Human
Unigene: 533471 Human
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