The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]
Function:
Acts as a transcriptional repressor.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitously expressed.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the ZHX family.
Contains 2 C2H2-type zinc fingers.
Contains 5 homeobox DNA-binding domains.
SWISS:
Q9UKY1
Gene ID:
11244
Database links:
Entrez Gene: 11244 Human
Entrez Gene: 420347 Chicken
Entrez Gene: 22770 Mouse
Entrez Gene: 171159 Rat
Omim: 604764 Human
SwissProt: Q9UKY1 Human
SwissProt: P70121 Mouse
SwissProt: Q8R515 Rat
Unigene: 612084 Human
Unigene: 244931 Mouse
Unigene: 16902 Rat
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