Myosin is a hexamer of two heavy chains (MHC) and four light chains (MLC) that interacts with Actin to generate the force for diverse cellular movements, including cytokinesis, phagocytosis and muscle contraction.
Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}.
Similarity:
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. {ECO:0000305}.
Contains 2 IQ domains.
Contains 1 myosin motor domain. {ECO:0000305}.
Contains 1 TH1 (class I myosin tail homology) domain.
SWISS:
Q8N1T3
Gene ID:
283446
Database links:
Entrez Gene: 283446 Human
Entrez Gene: 231646 Mouse
Omim: 614636 Human
SwissProt: Q8N1T3 Human
SwissProt: Q9D6A1 Mouse
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Sample:
Lane 1: U87MG (Human) Cell Lysate at 30 ug
Lane 2: Molt-4 (Human) Cell Lysate at 30 ug
Lane 3: Siha (Human) Cell Lysate at 30 ug
Lane 4: A549 (Human) Cell Lysate at 30 ug
Primary: Anti-MYO1H (SL19170R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 119 kD
Observed band size: 125 kD
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